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Hyodeoxycholic Acid (HDCA), chemically known as 3α,6α-dihydroxy-5β-cholan-24-oic acid, is a secondary bile acid formed via microbial conversion in the porcine gut. Widely recognized for its biological activities, HDCA has emerged as a crucial metabolic compound in human pharmacotherapy, veterinary health, and functional nutrition. It possesses distinct physicochemical characteristics compared to other dihydroxy bile acids, such as Chenodeoxycholic Acid (CDCA) or Ursodeoxycholic Acid (UDCA), primarily because of the spatial placement of its 6α-hydroxyl group.
As a leading OEM HDCA Bile Acid Manufacturers & Company, we prioritize structural purity, crystalline consistency, and regulatory alignment. The global pharmaceutical and veterinary sectors demand a secure, sustainable supply of HDCA, which requires clean source control, high-efficiency purification columns, and validated Analytical Methodologies (HPLC-ELSD / HPLC-MS). Under stringent GMP guidelines, our facility extracts and refines HDCA to exceed standard purity benchmarks (typically ≥98.0% by HPLC), ensuring its utility as a safe active pharmaceutical ingredient (API) or feed additive precursor.
Information Gain Metric: While traditional bile acid extraction processes struggle with heavy metal residues and microbial contamination, our integration of low-temperature countercurrent crystallization and multi-stage membrane filtration yields a high-density, low-ash crystalline powder optimized for oral formulations and high-solubility tablets.
The manufacturing architecture of HDCA is undergoing a structural transition. Currently, the most stable commercial method involves extraction from natural porcine bile fractions. This traditional route relies heavily on robust source tracking and certified slaughterhouse networks. However, to mitigate supply chain volatility and comply with animal welfare standards, our R&D center is mapping alternative bio-synthetic and enzymatic production pathways.
Our mid-term technical roadmap focuses on the enzymatic epimerization of CDCA or cholic acid intermediates using engineered hydroxysteroid dehydrogenases (HSDHs) in cell-free systems. This biocatalytic conversion route yields high stereospecificity, bypassing the generation of undesired isomers that are difficult to separate via conventional crystallization. By scaling up recombinant enzyme production, we aim to offer a purely semi-synthetic HDCA line that satisfies the strict non-animal origin requirements of specific global regulatory bodies.
Simultaneously, we are developing micro-encapsulation formulations for veterinary and food applications. Raw bile acids typically exhibit high bitterness and can cause mucosal irritation in concentrated doses. Using specialized ethylcellulose and lipid-based coating technologies, we produce a target-release microencapsulated HDCA. This formulation resists early gastric degradation, releasing specifically in the mid-to-distal jejunum where biological absorption is optimal.
At the macro level, bile acids are no longer viewed merely as emulsifiers for fat digestion. They are active signaling molecules that interact with nuclear receptors, notably the Farnesoid X Receptor (FXR) and the G-protein-coupled bile acid receptor 5 (TGR5). Our OEM partnership models focus on translating these biochemical properties into tailored macro-level applications:
Pharmaceutical Grade Applications: HDCA acts as a lead candidate for treating lipid metabolism disorders, non-alcoholic fatty liver disease (NAFLD), and hypercholesterolemia. It inhibits the expression of cholesterol 7α-hydroxylase (CYP7A1), thereby downregulating endogenous cholesterol synthesis and facilitating the dissolution of gallstones. Through custom chemical modifications, we support API manufacturers in converting bulk HDCA into novel therapeutic derivatives.
Veterinary & Animal Nutrition: In intensive livestock and aquaculture production, high-fat diets are common to accelerate growth. However, this often overburdens the hepatic systems of animals, leading to fatty liver disease, compromised immune defense, and high mortality rates. Integrating low-dose HDCA into commercial feed formulations stimulates bile secretion, enhances the activity of pancreatic lipase, and neutralizes endotoxins, resulting in improved feed conversion ratios (FCR) and lower mortality.
Established in 2012, Chengdu Chenlv Herb Co., Ltd. is a premier high-tech biotechnology enterprise specializing in the R&D, manufacturing, and distribution of premium botanical extracts and natural pharmaceutical raw materials. We provide high-purity, bio-active ingredients for the pharmaceutical, functional food, and cosmetic industries worldwide.
Our state-of-the-art manufacturing plant in Sichuan, China, integrates modern industrial automation with clean-room technology to guarantee consistent batch-to-batch reproducibility. By using high-throughput column chromatography, automated crystallization reactors, and closed-loop solvent recovery systems, we reduce energy consumption while maintaining a pristine chemical profile.
To secure supply chain resilience against raw material volatility, Chenlv Herb maintains direct supply contracts with major agricultural and biological collection networks. Our real-time ERP inventory management system monitors starting material flows, ensuring seamless, year-round production of HDCA and key botanical extracts, regardless of seasonal shifts.
Chenlv Herb seamlessly integrates scientific research, industrial-scale extraction, and contract formulation.
Leveraging advanced extraction technologies to concentrate active therapeutic components from botanicals. Our facility is equipped with multi-stage counter-current extractors, vacuum concentrators, and spray dryers.
Offering turnkey solutions for global distributors. From customized ingredient specs to complex biological synthesis and custom packaging, we tailor our systems to fit your specifications.
Choose our technical expertise and operational excellence to ensure high purity and reliable delivery.
R&D-focused synthesis protocols and structural modifications designed to elevate your brand value.
Automated manufacturing operations and green processing align with modern environmental values.
End-to-end biological resource tracking and green waste recovery solutions.
Rapid lead times, comprehensive custom parameters, and flexible batch configurations.
Equipped with advanced HPLC, GC, AAS, and microbial test labs monitoring every phase of production.
Over a decade of manufacturing expertise, delivering regulatory dossiers and analytical support.
Our ingredients are integrated into critical global health, medicinal, and nutritional frameworks.
Aligned with the concept of "medicine and food homology," our botanical fractions and purified bile acids satisfy strict safety profiles, supporting formulation designs targeting metabolic stability.
Providing high-purity active intermediates for synthesis pathways. Supported by detailed analytical validation dossiers, including heavy metal limits and crystalline profiling.
Natural, biocompatible raw materials with optimized solubility. Ideal for clean, safe cosmetic formulations seeking modern bioactive functional additives.
Enhancing biological feed performance. Incorporating bile acids supports liver function, facilitates fat-soluble nutrient absorption, and optimizes feed efficiency.
Chenlv Herb provides a streamlined contract manufacturing process to take your custom formulations from lab scale to industrial production.
Collaborating with clients to define chemical, physical, and packaging specifications.
Delivering clear commercial quotes based on raw material sourcing and purity specifications.
Finalizing quality control parameters, delivery terms, and intellectual property agreements.
Producing pilot-scale samples for chemical verification, purity validation, and customer approval.
Scheduling automated commercial production runs in compliance with ISO and GMP standards.
Testing every batch for active assay levels, contaminants, and heavy metal limits prior to release.
Arranging export logistics and customs documentation to ensure timely delivery to your destination.
Our operational standards are audited and certified by leading international bodies, ensuring complete regulatory alignment.
Procuring raw bile acids at commercial scale requires strict attention to chemical standards. Procurement teams must screen candidates based on specific criteria to minimize risk and avoid compliance issues. We provide detailed documentation to support your quality control evaluations.
When requesting samples or pricing for bulk HDCA, ensure the material meets the following standard criteria:
| Parameters | Standard Specification | Analytical Method |
|---|---|---|
| Active Assay (Purity) | ≥ 98.0% (Dry basis) | HPLC-ELSD |
| Physical Appearance | White to off-white crystalline powder | Visual Inspection |
| Loss on Drying | ≤ 1.0% | Gravimetric (105°C, 3 hours) |
| Heavy Metals (Pb, As, Hg, Cd) | ≤ 10 ppm total | ICP-MS |
| Total Aerobic Count | ≤ 1000 cfu/g | USP <61> / EP 2.6.12 |
Navigating different regulatory frameworks can be complex. As an established global exporter, Chengdu Chenlv Herb Co., Ltd. provides local warehouse logistics, customs clearance, and comprehensive compliance documentation to keep your operations running smoothly. We offer full regulatory support, including:
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Rich in epigallocatechin gallate (EGCG) to support weight management and antioxidant protection.
Inquire NowGet answers to key questions about sourcing, quality control, and the production parameters of HDCA.
Keep track of natural raw material trends, market updates, and upcoming global industry events.
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Chengdu Chenlv Herb invites partners and industry colleagues to connect at the 23rd China Pharmaceutical Raw Materials Exhibition (CPHI China) to explore new opportunities in plant extraction.
We invite you to join us at Guangzhou’s Import and Export Fair Exhibition Hall for the 92nd API China conference to discuss new developments in biotechnology.
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